Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
O43752
UPID:
STX6_HUMAN
Alternative names:
-
Alternative UPACC:
O43752; B2R652; B4DR17; Q5VY08; Q6FH83
Background:
Syntaxin-6 plays a pivotal role in cellular trafficking, specifically in the movement of transport vesicles to target membranes. It is instrumental in directing endosomes to the trans-Golgi network, potentially facilitating retrograde trafficking. In collaboration with SNARE STX12, Syntaxin-6 is crucial for the translocation of vesicles from endosomes to the cell membrane, highlighting its significance in the endocytic recycling pathway.
Therapeutic significance:
Understanding the role of Syntaxin-6 could open doors to potential therapeutic strategies. Its involvement in critical cellular processes underscores its potential as a target for therapeutic intervention in diseases where these pathways are disrupted.