Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
O43900
UPID:
PRIC3_HUMAN
Alternative names:
LIM domain only protein 6; Prickle-like protein 3; Triple LIM domain protein 6
Alternative UPACC:
O43900; B7Z8F2; O76007; Q53XR5
Background:
Prickle planar cell polarity protein 3, also known as Prickle-like protein 3, plays a crucial role in the planar cell polarity pathway, essential for cell polarization during developmental processes. It is a part of the core module that maintains cell polarity, involved in cilia growth, positioning, and the proper function of mitochondrial membrane ATP synthase.
Therapeutic significance:
The protein's modifier role in Leber hereditary optic neuropathy underscores its potential in therapeutic strategies targeting mitochondrial diseases, highlighting the importance of understanding its functions for developing treatments.