Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
O60231
UPID:
DHX16_HUMAN
Alternative names:
ATP-dependent RNA helicase #3; DEAH-box protein 16
Alternative UPACC:
O60231; O60322; Q5JP45; Q969X7; Q96QC1
Background:
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16, also known as ATP-dependent RNA helicase #3 and DEAH-box protein 16, plays a crucial role in pre-mRNA splicing as part of the spliceosome. It is involved in the splicing of U12-type introns and acts as a pattern recognition receptor in the innate antiviral response, enhancing RIGI-dependent immune responses.
Therapeutic significance:
DHX16's involvement in Neuromuscular oculoauditory syndrome, a disorder with a broad spectrum of symptoms, highlights its potential as a target for therapeutic intervention. Understanding the role of DHX16 could open doors to potential therapeutic strategies.