Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
O60256
UPID:
KPRB_HUMAN
Alternative names:
41 kDa phosphoribosypyrophosphate synthetase-associated protein
Alternative UPACC:
O60256; B4E1M8; B4E329; B7ZKZ1; E7EMY2; Q6IAS2
Background:
Phosphoribosyl pyrophosphate synthase-associated protein 2, also known as the 41 kDa phosphoribosypyrophosphate synthetase-associated protein, plays a crucial role in cellular metabolism. It is involved in the synthesis of 5-phosphoribose 1-diphosphate, a key precursor in the biosynthesis of nucleotides and nucleic acids. This protein's regulatory function ensures the balance of nucleotide production, which is essential for DNA and RNA synthesis.
Therapeutic significance:
Understanding the role of Phosphoribosyl pyrophosphate synthase-associated protein 2 could open doors to potential therapeutic strategies. Its involvement in nucleotide biosynthesis pathways makes it a candidate for research in diseases where nucleotide balance is disrupted.