Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
O60264
UPID:
SMCA5_HUMAN
Alternative names:
Sucrose nonfermenting protein 2 homolog
Alternative UPACC:
O60264
Background:
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5, also known as Sucrose nonfermenting protein 2 homolog, plays a pivotal role in chromatin remodeling. It exhibits intrinsic ATP-dependent nucleosome-remodeling activity, essential for DNA replication, transcription, and repair. This protein is a key component of ISWI chromatin-remodeling complexes, influencing nucleosome positioning and facilitating access to DNA by altering chromatin structure.
Therapeutic significance:
Understanding the role of SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 could open doors to potential therapeutic strategies.