Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
O60294
UPID:
TYW4_HUMAN
Alternative names:
Leucine carboxyl methyltransferase 2; tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase; tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase
Alternative UPACC:
O60294; Q4JFT6; Q96B55; Q9NR10
Background:
The tRNA wybutosine-synthesizing protein 4, also known as Leucine carboxyl methyltransferase 2, plays a crucial role in the wybutosine biosynthesis pathway. Wybutosine, a hypermodified guanosine found adjacent to the anticodon of eukaryotic phenylalanine tRNA, is essential for accurate protein synthesis. This protein's activity, involving the methylation of leucine residues, underscores its importance in tRNA modification and function.
Therapeutic significance:
Understanding the role of tRNA wybutosine-synthesizing protein 4 could open doors to potential therapeutic strategies. Its involvement in the critical process of tRNA modification highlights its potential as a target for interventions aimed at correcting protein synthesis disorders.