Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
O60303
UPID:
KATIP_HUMAN
Alternative names:
-
Alternative UPACC:
O60303; A7E2C2
Background:
Katanin-interacting protein plays a pivotal role in cellular dynamics, influencing the stability of microtubules. This is achieved possibly through its interaction with the microtubule-severing katanin complex, highlighting its critical function in cellular architecture and division.
Therapeutic significance:
Linked to Joubert syndrome 26, a disorder characterized by cerebellar ataxia and a host of other neurological symptoms, the study of Katanin-interacting protein offers a promising avenue for therapeutic intervention. Understanding the role of Katanin-interacting protein could open doors to potential therapeutic strategies.