Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
O60312
UPID:
AT10A_HUMAN
Alternative names:
ATPase class V type 10A; Aminophospholipid translocase VA; P4-ATPase flippase complex alpha subunit ATP10A
Alternative UPACC:
O60312; Q4G0S9; Q969I4
Background:
Phospholipid-transporting ATPase VA, also known as ATPase class V type 10A, plays a crucial role in cellular processes by catalyzing ATP hydrolysis to transport phosphatidylcholine across the plasma membrane. This action is vital for membrane bending and cell trafficking, influencing cell adhesion and spreading on the extracellular matrix.
Therapeutic significance:
Understanding the role of Phospholipid-transporting ATPase VA could open doors to potential therapeutic strategies.