Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
O60353
UPID:
FZD6_HUMAN
Alternative names:
-
Alternative UPACC:
O60353; B4DRN0; Q6N0A5; Q6P9C3; Q8WXR9
Background:
Frizzled-6, a receptor for Wnt proteins, plays a pivotal role in the Wnt signaling pathway. This pathway is crucial for various cellular processes, including cell proliferation, differentiation, and migration. Frizzled-6 is involved in the activation of disheveled proteins and the inhibition of GSK-3 kinase, leading to the accumulation of beta-catenin in the nucleus and the activation of Wnt target genes. Additionally, it has a role in tissue morphogenesis and the establishment of planar cell polarity, particularly in the inner ear.
Therapeutic significance:
Frizzled-6's involvement in the non-syndromic congenital nail disorder 1 highlights its potential as a therapeutic target. Understanding the role of Frizzled-6 could open doors to potential therapeutic strategies for treating this nail disorder and possibly other related conditions.