Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
O60481
UPID:
ZIC3_HUMAN
Alternative names:
Zinc finger protein 203; Zinc finger protein of the cerebellum 3
Alternative UPACC:
O60481; B2CNW4; Q14DE5; Q5JY75
Background:
Zinc finger protein ZIC 3, also known as Zinc finger protein 203 and Zinc finger protein of the cerebellum 3, plays a pivotal role in axial midline development and left-right asymmetry specification. It acts as a transcriptional activator, binding to the GLI-consensus sequence, essential for early developmental stages.
Therapeutic significance:
ZIC 3 is implicated in several congenital disorders, including Heterotaxy, visceral, 1, X-linked; VACTERL association X-linked with or without hydrocephalus; and multiple types of Congenital heart defects. Understanding the role of Zinc finger protein ZIC 3 could open doors to potential therapeutic strategies for these complex conditions.