Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
O60500
UPID:
NPHN_HUMAN
Alternative names:
Renal glomerulus-specific cell adhesion receptor
Alternative UPACC:
O60500; A6NDH2; C3RX61
Background:
Nephrin, known as a renal glomerulus-specific cell adhesion receptor, plays a crucial role in kidney function and skeletal muscle formation. It is pivotal in developing the kidney glomerular filtration barrier, regulating vascular permeability, and anchoring the podocyte slit diaphragm to the actin cytoskeleton.
Therapeutic significance:
Nephrin's involvement in Nephrotic syndrome 1, characterized by severe proteinuria and potential progression to end-stage renal failure, highlights its therapeutic significance. Understanding Nephrin's role could lead to novel treatments for this debilitating condition.