Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
O60513
UPID:
B4GT4_HUMAN
Alternative names:
Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase; Lactotriaosylceramide beta-1,4-galactosyltransferase; N-acetyllactosamine synthase; Nal synthase; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 4; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 4
Alternative UPACC:
O60513; Q68D68; Q9BSW3; Q9C078
Background:
Beta-1,4-galactosyltransferase 4, known by alternative names such as N-acetyllactosamine synthase and UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 4, plays a pivotal role in the synthesis of glycan chains on glycoproteins and glycosphingolipids. It is crucial for the construction and elongation of keratan sulfate proteoglycans, contributing to the generation of 6-sulfo-sialyl-Lewis X epitopes on mucin-type glycoproteins, which are essential for leukocyte migration.
Therapeutic significance:
Understanding the role of Beta-1,4-galactosyltransferase 4 could open doors to potential therapeutic strategies.