Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
O60610
UPID:
DIAP1_HUMAN
Alternative names:
Diaphanous-related formin-1
Alternative UPACC:
O60610; A6NF18; B7ZKW2; E9PEZ2; Q17RN4; Q59FH8; Q9UC76
Background:
Protein diaphanous homolog 1, also known as Diaphanous-related formin-1, plays a pivotal role in actin nucleation and elongation, essential for F-actin assembly. It regulates actin polymerization, crucial for cytokinesis, transcriptional activation, and cell migration. Its involvement in the MEMO1-RHOA-DIAPH1 signaling pathway is critical for microtubule stabilization at the cell cortex, influencing cell morphology and cytoskeletal organization.
Therapeutic significance:
Linked to Deafness, autosomal dominant 1, with or without thrombocytopenia, and Seizures, cortical blindness, and microcephaly syndrome, understanding the role of Protein diaphanous homolog 1 could open doors to potential therapeutic strategies.