Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
O60763
UPID:
USO1_HUMAN
Alternative names:
Protein USO1 homolog; Transcytosis-associated protein; Vesicle-docking protein
Alternative UPACC:
O60763; B2RAQ0; Q6PK63; Q86TB8; Q8N592
Background:
General vesicular transport factor p115, also known as Protein USO1 homolog, Transcytosis-associated protein, and Vesicle-docking protein, plays a crucial role in vesicular transport. It is indispensable for intercisternal transport within the Golgi stack, facilitating transcytotic fusion and binding of vesicles to target membranes. Its function as a vesicular anchor, maintaining proximity between vesicular and target membranes, underscores its importance in cellular logistics.
Therapeutic significance:
Understanding the role of General vesicular transport factor p115 could open doors to potential therapeutic strategies.