Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
O60888
UPID:
CUTA_HUMAN
Alternative names:
Acetylcholinesterase-associated protein; Brain acetylcholinesterase putative membrane anchor
Alternative UPACC:
O60888; A2AB26; A2BEL4; Q3B784; Q5JXM9; Q5SU05; Q9NYQ9
Background:
Protein CutA, also known as Acetylcholinesterase-associated protein, plays a crucial role in the complex network of membrane proteins linked to acetylcholinesterase (AChE). This association suggests its involvement in critical neurological processes, given AChE's pivotal role in breaking down acetylcholine, a neurotransmitter essential for muscle contraction and cognitive functions.
Therapeutic significance:
Understanding the role of Protein CutA could open doors to potential therapeutic strategies. Its connection with acetylcholinesterase hints at significant implications for treating neurological disorders, where modulation of acetylcholine levels is a key therapeutic strategy.