Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
O60894
UPID:
RAMP1_HUMAN
Alternative names:
Calcitonin-receptor-like receptor activity-modifying protein 1
Alternative UPACC:
O60894; Q6FGS5
Background:
Receptor activity-modifying protein 1 (RAMP1) plays a crucial role in transporting the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. It functions as a receptor for calcitonin-gene-related peptide (CGRP) alongside CALCRL, highlighting its pivotal role in cellular signaling pathways.
Therapeutic significance:
Understanding the role of Receptor activity-modifying protein 1 could open doors to potential therapeutic strategies. Its involvement in key signaling pathways offers a promising avenue for the development of novel treatments.