Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
O60895
UPID:
RAMP2_HUMAN
Alternative names:
Calcitonin-receptor-like receptor activity-modifying protein 2
Alternative UPACC:
O60895; A7L9S6; K7EMD3; Q8N1F2
Background:
Receptor activity-modifying protein 2 (RAMP2) plays a crucial role in cellular signaling by transporting the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. It also functions as a receptor for adrenomedullin (AM) in conjunction with CALCRL, highlighting its importance in physiological processes.
Therapeutic significance:
Understanding the role of Receptor activity-modifying protein 2 could open doors to potential therapeutic strategies. Its involvement in critical signaling pathways suggests its potential as a target for drug discovery, aiming to modulate its function for therapeutic benefits.