Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for receptors.
Fig. 1. The sreening workflow of Receptor.AI
This process includes extensive molecular simulations of the receptor in its native membrane environment, along with ensemble virtual screening that accounts for its conformational mobility. In the case of dimeric or oligomeric receptors, the entire functional complex is modelled, identifying potential binding pockets on and between the subunits to encompass all possible mechanisms of action.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
O75084
UPID:
FZD7_HUMAN
Alternative names:
FzE3
Alternative UPACC:
O75084; O94816; Q53S59; Q96B74
Background:
Frizzled-7, known alternatively as FzE3, is a receptor for Wnt proteins, playing a pivotal role in the Wnt signaling pathway. This pathway is crucial for various cellular processes, including cell proliferation, differentiation, and migration. Frizzled-7's involvement in both canonical and non-canonical Wnt signaling pathways underscores its multifaceted role in cellular communication and signal transduction.
Therapeutic significance:
Understanding the role of Frizzled-7 could open doors to potential therapeutic strategies. Its central role in Wnt signaling pathways makes it a promising target for drug discovery, particularly in diseases where Wnt signaling is dysregulated.