Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
O75129
UPID:
ASTN2_HUMAN
Alternative names:
-
Alternative UPACC:
O75129; A2A2T7; A2A2T9; Q52LQ2; Q5JVX8; Q5JVX9; Q5JVY1; Q5VXG8; Q5VZX6; Q8N6P8; Q8WV47; Q96FL4; Q9UHW6
Background:
Astrotactin-2, encoded by the gene O75129, plays a crucial role in neuronal development. It mediates the recycling of the neuronal cell adhesion molecule ASTN1, facilitating its internalization and transport in migrating neurons. This protein's unique ability to selectively bind various inositol phosphates indicates its involvement in membrane-associated processes.
Therapeutic significance:
Understanding the role of Astrotactin-2 could open doors to potential therapeutic strategies. Its pivotal function in neuronal migration and cell adhesion positions it as a key target for research in neurodevelopmental disorders.