Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
O75161
UPID:
NPHP4_HUMAN
Alternative names:
Nephroretinin
Alternative UPACC:
O75161; Q8IWC0
Background:
Nephrocystin-4, also known as Nephroretinin, plays a crucial role in the organization of apical junctions and the subapical actin network in multiciliated epithelial cells. It is part of a NPHP1-4-8 module essential for building functional cilia and is involved in several signaling pathways, including the down-regulation of the canonical Wnt pathway and the negative regulation of the hippo pathway.
Therapeutic significance:
Nephrocystin-4 is implicated in Nephronophthisis 4 and Senior-Loken syndrome 4, both of which are characterized by renal disease and, in the case of Senior-Loken syndrome, additional eye disease. Understanding the role of Nephrocystin-4 could open doors to potential therapeutic strategies for these conditions.