Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for receptors.
Fig. 1. The sreening workflow of Receptor.AI
It features thorough molecular simulations of the receptor within its native membrane environment, complemented by ensemble virtual screening that considers its conformational mobility. For dimeric or oligomeric receptors, the full functional complex is constructed, and tentative binding sites are determined on and between the subunits to cover the entire spectrum of potential mechanisms of action.
Our library stands out due to several important features:
partner
Reaxense
upacc
O75311
UPID:
GLRA3_HUMAN
Alternative names:
-
Alternative UPACC:
O75311; D3DP44; O75816; Q5D0E3
Background:
Glycine receptor subunit alpha-3 is a pivotal component of glycine receptors, which are ligand-gated chloride channels. These channels, activated by extracellular glycine, play a crucial role in modulating neuronal excitability and are involved in generating inhibitory postsynaptic currents. Their function is influenced by subunit composition, with heteropentameric channels exhibiting faster closure.
Therapeutic significance:
Understanding the role of Glycine receptor subunit alpha-3 could open doors to potential therapeutic strategies. Its involvement in down-regulating neuronal excitability and contributing to pain perception highlights its potential as a target in treating neurological disorders and pain management.