Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
O75381
UPID:
PEX14_HUMAN
Alternative names:
PTS1 receptor-docking protein; Peroxin-14; Peroxisomal membrane anchor protein PEX14
Alternative UPACC:
O75381; B2R7N1; B3KML6; B7Z1N2; Q8WX51
Background:
Peroxisomal membrane protein PEX14, also known as PTS1 receptor-docking protein or Peroxin-14, is a crucial component of the PEX13-PEX14 docking complex. This complex facilitates the import of peroxisomal cargo proteins by forming a large import pore, allowing for the translocation of cargo into the peroxisome matrix. PEX14 plays a vital role in peroxisome movement through its interaction with tubulin.
Therapeutic significance:
PEX14 is linked to peroxisome biogenesis disorders, including Zellweger syndrome and neonatal adrenoleukodystrophy, diseases characterized by severe neurologic dysfunction and liver dysfunction. Understanding the role of PEX14 could open doors to potential therapeutic strategies for these peroxisomal disorders.