Focused On-demand Library for Vacuolar protein sorting-associated protein 26A

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.

We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.

In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.

We utilise our cutting-edge, exclusive workflow to develop focused libraries.

Fig. 1. The sreening workflow of Receptor.AI

Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.

Key features that set our library apart include:

The Receptor.AI platform integrates extensive information about the target protein, such as historical experiments, academic research, known ligands, and structural insights, thereby increasing the likelihood of identifying highly relevant compounds.
The platform’s sophisticated molecular simulations are designed to discover potential binding sites, ensuring that our focused library is optimal for the discovery of allosteric inhibitors and binders for cryptic pockets.
With over 50 customisable AI models, verified through extensive testing in commercial drug discovery and research, Receptor.AI is efficient, reliable, and precise. These models are essential in the production of our focused libraries.
Receptor.AI not only produces focused libraries but also provides full services and solutions at every stage of preclinical drug discovery, with a success-based pricing structure that aligns our interests with the success of your project.

partner

Reaxense

upacc

O75436

UPID:

VP26A_HUMAN

Alternative names:

Vesicle protein sorting 26A

Alternative UPACC:

O75436; A8MZ56; B2RDD3; Q8TBH4; Q9H982

Background:

Vacuolar protein sorting-associated protein 26A (VPS26A) plays a pivotal role in the retromer complex, essential for the retrograde transport of proteins from endosomes to the Golgi network. It prevents the misrouting of transmembrane proteins to lysosomal degradation pathways, facilitating the recycling of cargo proteins. VPS26A's involvement in various pathways, including the SNX-BAR, SNX3, and SNX27-retromer pathways, underscores its critical function in cellular trafficking and signaling.

Therapeutic significance:

Understanding the role of Vacuolar protein sorting-associated protein 26A could open doors to potential therapeutic strategies.