Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
O75448
UPID:
MED24_HUMAN
Alternative names:
Activator-recruited cofactor 100 kDa component; Cofactor required for Sp1 transcriptional activation subunit 4; Mediator complex subunit 24; Thyroid hormone receptor-associated protein 4; Thyroid hormone receptor-associated protein complex 100 kDa component; Vitamin D3 receptor-interacting protein complex 100 kDa component
Alternative UPACC:
O75448; A8K4S5; B3KMR9; Q14143; Q9NNY5
Background:
Mediator of RNA polymerase II transcription subunit 24 plays a pivotal role in the Mediator complex, essential for the transcription of nearly all RNA polymerase II-dependent genes. It acts as a bridge, facilitating the transfer of information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. This protein is known by several alternative names, including Activator-recruited cofactor 100 kDa component and Thyroid hormone receptor-associated protein 4, highlighting its diverse interactions and functions within the cell.
Therapeutic significance:
Understanding the role of Mediator of RNA polymerase II transcription subunit 24 could open doors to potential therapeutic strategies.