Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
O75477
UPID:
ERLN1_HUMAN
Alternative names:
Endoplasmic reticulum lipid raft-associated protein 1; Protein KE04; Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1
Alternative UPACC:
O75477; B0QZ42; D3DR65; Q53HV0
Background:
Erlin-1, also known as Endoplasmic reticulum lipid raft-associated protein 1, plays a crucial role in the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors. It is pivotal in regulating cellular cholesterol homeostasis through the SREBP signaling pathway and binds cholesterol, potentially influencing the ER retention of the SCAP-SREBF complex.
Therapeutic significance:
Erlin-1's involvement in Spastic paraplegia 62, an autosomal recessive neurodegenerative disorder, underscores its therapeutic significance. Understanding the role of Erlin-1 could open doors to potential therapeutic strategies for managing this condition and improving patient outcomes.