Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
O75486
UPID:
SUPT3_HUMAN
Alternative names:
SPT3-like protein
Alternative UPACC:
O75486; A6NKG9; B2R9Q5; O76066; Q5TAV9; Q86VN7
Background:
The Transcription initiation protein SPT3 homolog, also known as SPT3-like protein, plays a pivotal role as a probable transcriptional activator. Its involvement in the initiation of transcription highlights its fundamental importance in gene expression regulation.
Therapeutic significance:
Understanding the role of Transcription initiation protein SPT3 homolog could open doors to potential therapeutic strategies. Its critical function in transcription initiation positions it as a key target for drug discovery efforts aimed at modulating gene expression.