Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
O75525
UPID:
KHDR3_HUMAN
Alternative names:
RNA-binding protein T-Star; Sam68-like mammalian protein 2; Sam68-like phosphotyrosine protein
Alternative UPACC:
O75525; Q6NUL8; Q9UPA8
Background:
KH domain-containing, RNA-binding, signal transduction-associated protein 3, also known as RNA-binding protein T-Star, Sam68-like mammalian protein 2, and Sam68-like phosphotyrosine protein, plays a pivotal role in the regulation of alternative splicing. It influences mRNA splice site selection and exon inclusion, with a preference for the 5'-[AU]UAAA-3' motif. This protein's RNA-binding abilities are modulated by tyrosine kinase PTK6, affecting splice site selection of key growth factors and regulating CD44 alternative splicing. It also plays a role in the neuronal glutamatergic synapse function and plasticity through targeted splicing regulation of NRXN1.
Therapeutic significance:
Understanding the role of KH domain-containing, RNA-binding, signal transduction-associated protein 3 could open doors to potential therapeutic strategies.