Focused On-demand Library for TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.

The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.

The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.

Our high-tech, dedicated method is applied to construct targeted libraries.

Fig. 1. The sreening workflow of Receptor.AI

Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.

Key features that set our library apart include:

The Receptor.AI platform integrates extensive information about the target protein, such as historical experiments, academic research, known ligands, and structural insights, thereby increasing the likelihood of identifying highly relevant compounds.
The platform’s sophisticated molecular simulations are designed to discover potential binding sites, ensuring that our focused library is optimal for the discovery of allosteric inhibitors and binders for cryptic pockets.
With over 50 customisable AI models, verified through extensive testing in commercial drug discovery and research, Receptor.AI is efficient, reliable, and precise. These models are essential in the production of our focused libraries.
Receptor.AI not only produces focused libraries but also provides full services and solutions at every stage of preclinical drug discovery, with a success-based pricing structure that aligns our interests with the success of your project.

partner

Reaxense

upacc

O75529

UPID:

TAF5L_HUMAN

Alternative names:

PCAF-associated factor 65 beta

Alternative UPACC:

O75529; Q5TDI5; Q5TDI6; Q8IW31

Background:

TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L, also known as PCAF-associated factor 65 beta, is a crucial component of the PCAF complex. This complex is known for its efficient acetylation of histones within a nucleosomal context, mirroring the functionality of the yeast SAGA complex. It plays a pivotal role in epigenetic regulation, essential for somatic reprogramming, through H3K9ac deposition and MYC recruitment, orchestrating gene expression programs that maintain the embryonic stem cell state.

Therapeutic significance:

Understanding the role of TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L could open doors to potential therapeutic strategies.