Focused On-demand Library for GTPase Era, mitochondrial

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.

Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.

The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.

Our top-notch dedicated system is used to design specialised libraries.

Fig. 1. The sreening workflow of Receptor.AI

Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.

Our library distinguishes itself through several key aspects:

The Receptor.AI platform integrates all available data about the target protein, including past experiments, literature data, known ligands, structural information and more. This consolidated approach maximises the probability of prioritising highly relevant compounds.
The platform uses sophisticated molecular simulations to identify possible binding sites so that the compounds in the focused library are suitable for discovering allosteric inhibitors and the binders for cryptic pockets.
The platform integrates over 50 highly customisable AI models, which are thoroughly tested and validated on a multitude of commercial drug discovery programs and research projects. It is designed to be efficient, reliable and accurate. All this power is utilised when producing the focused libraries.
In addition to producing the focused libraries, Receptor.AI provides services and end-to-end solutions at every stage of preclinical drug discovery. The pricing model is success-based, which reduces your risks and leverages the mutual benefits of the project's success.

partner

Reaxense

upacc

O75616

UPID:

ERAL1_HUMAN

Alternative names:

Conserved ERA-like GTPase; ERA-W; ERA-like protein 1

Alternative UPACC:

O75616; B3KN21; C9JEC6; O75617; Q8WUY4; Q96LE2; Q96TC0

Background:

The GTPase Era, mitochondrial, also known as Conserved ERA-like GTPase, ERA-W, and ERA-like protein 1, plays a crucial role in mitochondrial ribosomal small subunit assembly. It specifically binds the 12S mitochondrial rRNA to a 33 nucleotide section, delineating the 3' terminal stem-loop region, acting as a chaperone for the 12S mt-rRNA during ribosomal assembly.

Therapeutic significance:

Linked to Perrault syndrome 6, a disorder characterized by sensorineural deafness and, in females, ovarian dysgenesis, the study of GTPase Era, mitochondrial, offers a pathway to understanding and potentially treating this autosomal recessive disease.