Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
O75688
UPID:
PPM1B_HUMAN
Alternative names:
Protein phosphatase 2C isoform beta
Alternative UPACC:
O75688; Q461Q2; Q4J6C1; Q4J6C2; Q658R4; Q96ER6; Q9HAY8
Background:
Protein phosphatase 1B, also known as Protein phosphatase 2C isoform beta, is an enzyme with broad specificity. It plays a crucial role in cellular processes by dephosphorylating key proteins such as CDK2, CDK6, PRKAA1, PRKAA2, and IKBKB/IKKB. Its activity is pivotal in regulating cell cycle progression, energy metabolism, and inflammatory responses by terminating TNF-alpha-mediated NF-kappa-B activation.
Therapeutic significance:
Understanding the role of Protein phosphatase 1B could open doors to potential therapeutic strategies. Its involvement in critical signaling pathways offers a unique opportunity to modulate various diseases by targeting its enzymatic activity.