Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
O75694
UPID:
NU155_HUMAN
Alternative names:
155 kDa nucleoporin; Nucleoporin Nup155
Alternative UPACC:
O75694; Q9UBE9; Q9UFL5
Background:
Nuclear pore complex protein Nup155, also known as a 155 kDa nucleoporin, plays a pivotal role in the nuclear pore complex, essential for nucleocytoplasmic transport. Its involvement in binding and translocating proteins across the nuclear envelope underscores its significance in cellular function and embryogenesis.
Therapeutic significance:
Nup155's link to Atrial fibrillation, familial, 15, a cardiac rhythm disturbance, highlights its potential as a therapeutic target. Understanding the role of Nuclear pore complex protein Nup155 could open doors to potential therapeutic strategies for managing atrial fibrillation and improving cardiac health.