Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
O75900
UPID:
MMP23_HUMAN
Alternative names:
Femalysin; MIFR-1; Matrix metalloproteinase-21; Matrix metalloproteinase-22
Alternative UPACC:
O75900; A2AGN0; A2AGN1; O75894; O75895; Q5QPQ8; Q76P96; Q7LDM6; Q7LDM7; Q9UBR9; Q9UJK8
Background:
Matrix metalloproteinase-23, known by alternative names such as Femalysin, MIFR-1, and Matrix metalloproteinases 21 and 22, plays a crucial role as a protease. It is implicated in regulating the surface expression of potassium channels by retaining them in the endoplasmic reticulum, showcasing its significance in cellular processes.
Therapeutic significance:
Understanding the role of Matrix metalloproteinase-23 could open doors to potential therapeutic strategies. Its involvement in key cellular mechanisms highlights its potential as a target for drug discovery, aiming to modulate potassium channel activities for therapeutic benefits.