Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
O76036
UPID:
NCTR1_HUMAN
Alternative names:
Lymphocyte antigen 94 homolog; NK cell-activating receptor; Natural killer cell p46-related protein
Alternative UPACC:
O76036; B0V3L2; B0V3L3; B0V3L4; B0V3L5; B8JL03; O76016; O76017; O76018
Background:
Natural cytotoxicity triggering receptor 1, also known as Lymphocyte antigen 94 homolog, NK cell-activating receptor, and Natural killer cell p46-related protein, plays a pivotal role in the immune system's defense mechanisms. Its primary function involves activating cytotoxicity in natural killer (NK) cells, enhancing their ability to lyse tumor cells efficiently.
Therapeutic significance:
Understanding the role of Natural cytotoxicity triggering receptor 1 could open doors to potential therapeutic strategies. Its involvement in activating NK cells to target and destroy tumor cells highlights its potential as a target for cancer immunotherapy.