Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
O76071
UPID:
CIAO1_HUMAN
Alternative names:
WD repeat-containing protein 39
Alternative UPACC:
O76071; A0MNN9; Q53FM5
Background:
Probable cytosolic iron-sulfur protein assembly protein CIAO1, also known as WD repeat-containing protein 39, plays a crucial role in the cytosolic iron-sulfur protein assembly (CIA) complex. This complex is essential for the incorporation of iron-sulfur clusters into extramitochondrial Fe/S proteins, influencing various cellular processes. CIAO1's interaction with CIAO2A or CIAO2B and MMS19 facilitates the assembly of cytosolic-nuclear Fe/S proteins and has specific functions in modulating the transactivation activity of WT1 and in chromosome segregation.
Therapeutic significance:
Understanding the role of Probable cytosolic iron-sulfur protein assembly protein CIAO1 could open doors to potential therapeutic strategies.