Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
O76094
UPID:
SRP72_HUMAN
Alternative names:
Signal recognition particle 72 kDa protein
Alternative UPACC:
O76094; G5E9Z8; Q7Z3C0
Background:
The Signal Recognition Particle Subunit SRP72, a 72 kDa protein, plays a pivotal role in the signal recognition particle (SRP) complex. This complex is essential for the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER), ensuring proper protein folding and functionality. SRP72 binds the signal recognition particle RNA (7SL RNA) in the presence of SRP68, showcasing its critical role in protein translocation and cellular homeostasis.
Therapeutic significance:
Given its fundamental role in protein targeting and translocation, SRP72's dysfunction is linked to Bone Marrow Failure Syndrome 1, characterized by aplastic anemia and myelodysplasia. Understanding the role of Signal Recognition Particle Subunit SRP72 could open doors to potential therapeutic strategies for treating this autosomal dominant disease.