Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
O94762
UPID:
RECQ5_HUMAN
Alternative names:
DNA helicase, RecQ-like type 5; RecQ protein-like 5
Alternative UPACC:
O94762; Q6P4G0; Q9H0B1; Q9P1W7; Q9UNC8
Background:
ATP-dependent DNA helicase Q5, also known as DNA helicase, RecQ-like type 5 or RecQ protein-like 5, is pivotal in DNA replication, transcription, and repair. It binds to RNA polymerase II and POLR1A, enhancing genomic stability and ribosomal DNA array stability. This protein is crucial for mitotic chromosome separation, DNA repair, including inter-strand cross-link repair, and prevents homologous recombination.
Therapeutic significance:
Understanding the role of ATP-dependent DNA helicase Q5 could open doors to potential therapeutic strategies.