Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
O94811
UPID:
TPPP_HUMAN
Alternative names:
25 kDa brain-specific protein; TPPP/p25; p24; p25-alpha
Alternative UPACC:
O94811
Background:
Tubulin polymerization-promoting protein, also known as TPPP/p25, plays a crucial role in myelination, enhancing the elongation of the myelin sheath. It acts as a microtubule nucleation factor in oligodendrocytes, promoting microtubule nucleation at the Golgi outpost, essential for myelin sheath elongation. TPPP/p25 is vital for microtubule dynamics, offering both stabilization and bundling, and regulates cell migration and proliferation by interacting with HDAC6 and affecting tubulin acetylation.
Therapeutic significance:
Understanding the role of Tubulin polymerization-promoting protein could open doors to potential therapeutic strategies.