Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
O94826
UPID:
TOM70_HUMAN
Alternative names:
Mitochondrial precursor proteins import receptor; Translocase of outer membrane 70 kDa subunit; Translocase of outer mitochondrial membrane protein 70
Alternative UPACC:
O94826; D3DN48
Background:
The Mitochondrial import receptor subunit TOM70 plays a crucial role in cellular energy production. It acts as a receptor in the TOM complex, facilitating the translocation of mitochondrial preproteins from the cytosol into the mitochondria. This process is essential for mitochondrial function and energy production. TOM70 also has a vital role in antiviral responses, particularly in mediating TBK1 and IRF3 activation in response to Sendai virus infection.
Therapeutic significance:
Understanding the role of Mitochondrial import receptor subunit TOM70 could open doors to potential therapeutic strategies. Its involvement in mitochondrial function and antiviral responses makes it a promising target for developing treatments for diseases related to mitochondrial dysfunction and viral infections.