Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
O94827
UPID:
PKHG5_HUMAN
Alternative names:
Guanine nucleotide exchange factor 720
Alternative UPACC:
O94827; B3KU07; B7Z2M3; B7Z5X2; F5GZ21; F5H1I0; Q5SY17; Q5T8W5; Q5T8W9; Q6ZNM0; Q7Z436; Q86YD8; Q96BS1
Background:
Pleckstrin homology domain-containing family G member 5, also known as Guanine nucleotide exchange factor 720, plays a pivotal role in neuronal cell differentiation and angiogenesis. It functions as a guanine exchange factor for RAB26, regulating autophagy of synaptic vesicles in motoneurons' axon terminals. Additionally, it influences macrophage and osteoclast migration, adhesion, and matrix/bone degradation.
Therapeutic significance:
This protein's involvement in Distal spinal muscular atrophy, autosomal recessive, 4, and Charcot-Marie-Tooth disease, recessive intermediate C, underscores its potential as a target for therapeutic intervention. Understanding the role of Pleckstrin homology domain-containing family G member 5 could open doors to potential therapeutic strategies.