Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
O95149
UPID:
SPN1_HUMAN
Alternative names:
RNA U transporter 1
Alternative UPACC:
O95149; A6NE34; A8K0B0; D3DW76
Background:
Snurportin-1, also known as RNA U transporter 1, plays a crucial role in cellular function by facilitating the nuclear import of U snRNPs. This process is essential for pre-mRNA splicing, a critical step in gene expression. Snurportin-1 specifically recognizes and binds to the m3G-cap of U snRNAs, ensuring their proper localization within the nucleus.
Therapeutic significance:
Understanding the role of Snurportin-1 could open doors to potential therapeutic strategies. Its pivotal function in mRNA processing highlights its importance in cellular biology and disease mechanisms, making it a target of interest for drug discovery efforts aimed at modulating gene expression.