Focused On-demand Library for Netrin receptor UNC5C

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.

From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.

The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.

Our high-tech, dedicated method is applied to construct targeted libraries.

Fig. 1. The sreening workflow of Receptor.AI

Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.

Our library is unique due to several crucial aspects:

Receptor.AI compiles all relevant data on the target protein, such as past experimental results, literature findings, known ligands, and structural data, thereby enhancing the likelihood of focusing on the most significant compounds.
By utilizing advanced molecular simulations, the platform is adept at locating potential binding sites, rendering the compounds in the focused library well-suited for unearthing allosteric inhibitors and binders for hidden pockets.
The platform is supported by more than 50 highly specialized AI models, all of which have been rigorously tested and validated in diverse drug discovery and research programs. Its design emphasizes efficiency, reliability, and accuracy, crucial for producing focused libraries.
Receptor.AI extends beyond just creating focused libraries; it offers a complete spectrum of services and solutions during the preclinical drug discovery phase, with a success-dependent pricing strategy that reduces risk and fosters shared success in the project.

partner

Reaxense

upacc

O95185

UPID:

UNC5C_HUMAN

Alternative names:

Protein unc-5 homolog 3; Protein unc-5 homolog C

Alternative UPACC:

O95185; Q8IUT0

Background:

Netrin receptor UNC5C, also known as Protein unc-5 homolog 3 or C, plays a pivotal role in axon guidance by mediating axon repulsion in the developing nervous system. It interacts with NTN1/Netrin-1, influencing microtubule dynamics and axon repulsion. Additionally, UNC5C is involved in corticospinal tract axon guidance and dorsal root ganglion axon projection, acting as a dependence receptor for apoptosis induction in the absence of netrin ligand.

Therapeutic significance:

Given its involvement in Alzheimer's disease, characterized by neurodegeneration and amyloid-beta protein deposition, UNC5C's understanding could pave the way for innovative therapeutic strategies targeting neurodegenerative disorders.