Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
O95185
UPID:
UNC5C_HUMAN
Alternative names:
Protein unc-5 homolog 3; Protein unc-5 homolog C
Alternative UPACC:
O95185; Q8IUT0
Background:
Netrin receptor UNC5C, also known as Protein unc-5 homolog 3 or C, plays a pivotal role in axon guidance by mediating axon repulsion in the developing nervous system. It interacts with NTN1/Netrin-1, influencing microtubule dynamics and axon repulsion. Additionally, UNC5C is involved in corticospinal tract axon guidance and dorsal root ganglion axon projection, acting as a dependence receptor for apoptosis induction in the absence of netrin ligand.
Therapeutic significance:
Given its involvement in Alzheimer's disease, characterized by neurodegeneration and amyloid-beta protein deposition, UNC5C's understanding could pave the way for innovative therapeutic strategies targeting neurodegenerative disorders.