Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
O95256
UPID:
I18RA_HUMAN
Alternative names:
Accessory protein-like; CD218 antigen-like family member B; CDw218b; IL-1R accessory protein-like; Interleukin-1 receptor 7; Interleukin-18 receptor accessory protein-like; Interleukin-18 receptor beta
Alternative UPACC:
O95256; B2RPJ3; Q2QDE5; Q3KPE7; Q3KPE8; Q53TT4; Q53TU5
Background:
The Interleukin-18 receptor accessory protein, known by alternative names such as Accessory protein-like and IL-1R accessory protein-like, plays a crucial role in immune response regulation. It is part of the IL18 receptor complex, facilitating IL18-dependent signal transduction, which activates NF-kappa-B and JNK. This protein is instrumental in IFNG synthesis from T-helper 1 cells, highlighting its significance in immune system functionality.
Therapeutic significance:
Understanding the role of Interleukin-18 receptor accessory protein could open doors to potential therapeutic strategies. Its involvement in key immune response pathways suggests its potential as a target for modulating immune responses in various conditions.