Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
O95425
UPID:
SVIL_HUMAN
Alternative names:
Archvillin; p205/p250
Alternative UPACC:
O95425; D3DRW9; M1J557; O60611; O60612; Q5VZK5; Q5VZK6; Q9H1R7
Background:
Supervillin, known by its alternative names Archvillin and p205/p250, plays a pivotal role in cellular mechanics and structure. It forms a high-affinity link between the actin cytoskeleton and the membrane, contributing to myogenic membrane structure and differentiation. Its involvement in myosin II assembly and modulation, as well as its role in cell migration and cytokinesis, underscores its importance in cellular dynamics.
Therapeutic significance:
Linked to Myopathy, myofibrillar, 10, a disorder characterized by muscle pain and progressive rigidity, Supervillin's genetic variants highlight its clinical relevance. Understanding the role of Supervillin could open doors to potential therapeutic strategies for treating such neuromuscular disorders.