Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
O95741
UPID:
CPNE6_HUMAN
Alternative names:
Copine VI; Neuronal-copine
Alternative UPACC:
O95741; B2RAG6; B7Z1M3; D3DS55; F5GXN1; Q53HA6; Q8WVG1
Background:
Copine-6, also known as Copine VI or Neuronal-copine, is a calcium-dependent phospholipid-binding protein. It plays a pivotal role in calcium-mediated intracellular processes, including dendrite formation by melanocytes. Its ability to bind phospholipid membranes in a calcium-dependent manner underscores its significance in cellular signaling and structural organization.
Therapeutic significance:
Understanding the role of Copine-6 could open doors to potential therapeutic strategies. Its involvement in dendrite formation highlights its importance in neuronal function and development, suggesting that targeting Copine-6 could offer new avenues for treating neurological disorders.