Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
O96011
UPID:
PX11B_HUMAN
Alternative names:
Peroxin-11B; Peroxisomal biogenesis factor 11B; Protein PEX11 homolog beta
Alternative UPACC:
O96011; B3KN85; B4DXH9; Q96ET2
Background:
Peroxisomal membrane protein 11B, also known as Peroxin-11B, plays a crucial role in peroxisomal proliferation. It is instrumental in regulating peroxisome division by facilitating the recruitment of the dynamin-related GTPase DNM1L to the peroxisomal membrane, promoting membrane protrusion and elongation.
Therapeutic significance:
Peroxisomal membrane protein 11B is linked to Peroxisome biogenesis disorder 14B, characterized by mild intellectual disability, congenital cataracts, and progressive hearing loss. Understanding its role could lead to novel therapeutic strategies for this disorder.