Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P00797
UPID:
RENI_HUMAN
Alternative names:
Angiotensinogenase
Alternative UPACC:
P00797; Q6FI38; Q6T5C2
Background:
Renin, also known as Angiotensinogenase, plays a pivotal role in the regulation of blood pressure and electrolyte balance. As a specific endopeptidase, its primary function is to catalyze the conversion of angiotensinogen to angiotensin I, initiating a series of reactions that elevate blood pressure and enhance sodium retention by the kidneys.
Therapeutic significance:
Given its crucial role in blood pressure regulation, Renin is directly implicated in renal tubular dysgenesis and autosomal dominant tubulointerstitial kidney disease. These conditions underscore the therapeutic potential of targeting Renin in managing renal disorders and hypertension, offering a promising avenue for drug discovery and development.