Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
P01579
UPID:
IFNG_HUMAN
Alternative names:
Immune interferon
Alternative UPACC:
P01579; B5BU88; Q53ZV4
Background:
Interferon gamma, also known as immune interferon, is a critical cytokine produced by T-cells and NK cells. It plays pivotal roles in antimicrobial, antiviral, and antitumor responses, primarily signaling through the JAK-STAT pathway. This protein is instrumental in activating immune cells, enhancing antigen presentation, and regulating gene expression to drive a robust immune response.
Therapeutic significance:
Interferon gamma's involvement in diseases such as Aplastic anemia and Immunodeficiency 69 highlights its therapeutic potential. Its role in enhancing antigen presentation and modulating immune responses suggests that targeting this cytokine could lead to innovative treatments for these conditions. Understanding the role of Interferon gamma could open doors to potential therapeutic strategies.