Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
P02689
UPID:
MYP2_HUMAN
Alternative names:
Peripheral myelin protein 2
Alternative UPACC:
P02689; Q6FHL4
Background:
Myelin P2 protein, also known as Peripheral myelin protein 2, plays a crucial role in the nervous system's health by potentially participating in lipid transport within Schwann cells. It may also bind cholesterol, indicating its significance in maintaining myelin sheath integrity.
Therapeutic significance:
Linked to Charcot-Marie-Tooth disease, demyelinating, 1G, Myelin P2 protein's dysfunction underscores its therapeutic importance. Understanding its role could unveil novel strategies for treating this peripheral nervous system disorder, characterized by muscle weakness and atrophy.