Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
P02753
UPID:
RET4_HUMAN
Alternative names:
Plasma retinol-binding protein
Alternative UPACC:
P02753; D3DR38; O43478; O43479; Q5VY24; Q8WWA3; Q9P178
Background:
Retinol-binding protein 4 (RBP4) functions as a key mediator of retinol transport in blood plasma, crucial for delivering vitamin A from liver stores to peripheral tissues. It plays a pivotal role in the visual cycle by transferring retinol to STRA6, facilitating its cellular uptake.
Therapeutic significance:
RBP4's dysfunction is linked to Retinal dystrophy, iris coloboma, and comedogenic acne syndrome, characterized by retinal degeneration and severe acne, due to serum retinol deficiency. Understanding RBP4's role could lead to novel treatments for these conditions.