Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
P02778
UPID:
CXL10_HUMAN
Alternative names:
10 kDa interferon gamma-induced protein; Small-inducible cytokine B10
Alternative UPACC:
P02778; Q96QJ5
Background:
C-X-C motif chemokine 10 (CXCL10), also known as 10 kDa interferon gamma-induced protein or Small-inducible cytokine B10, plays a pivotal role in immune responses. It is a pro-inflammatory cytokine involved in processes such as chemotaxis, cell differentiation, and activation of peripheral immune cells. CXCL10's interaction with the CXCR3 receptor activates G protein-mediated signaling, leading to intracellular calcium production and actin reorganization. This facilitates the recruitment of Th1 lymphocytes at inflammation sites and is crucial for neuronal reorganization post-brain injury.
Therapeutic significance:
Understanding the role of C-X-C motif chemokine 10 could open doors to potential therapeutic strategies.